Breaking the Cycle of Negative Feedback to Enhance Cancer Immunotherapy

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KU Leuven researchers discover how to break the negative feedback loop to improve cancer immunotherapy. Over the past years, immunotherapy has improved the outlook for many cancer patients. However, not all cancers respond to current immunotherapies. A research team led by KU Leuven discovered a key mechanism behind this lack of response, and it came up with an innovative solution. A ’next-generation’ cancer vaccine-driven strategy will soon be tested in clinical trials with human patients.

Immunotherapy focuses on activating the patient’s own immune system to respond against the tumor(s) by administering a specific therapy. One of these drugs can be seen as a form of vaccination. ...

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