Doctoral scholarship holder, FLASH radiotherapy and radiobiology
|Lieu de travail||Antwerpen, Région flamande, Belgique|
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Department: Molecular Imaging - Pathology - Radiotherapy - Oncology Regime Full-time
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The Center for Oncological Research in collaboration with Iridium Netwerk is looking for a full-time (100%) doctoral scholarship holder, funded by a Kom Op Tegen Kanker grant in the field of FLASH radiotherapy and radiobiology. The title of the project is:
FLASH radiation therapy to improve the therapeutic management of breast cancer by reducing radiation-induced skin, soft tissue, lung and heart toxicities.
The FLASH effect, obtained with radiation therapy delivered at ultra-high dose rate (FLASH-RT), is defined as sparing normal tissues while maintaining the tumour effect, when compared to conventional dose-rate radiation therapy (CONV-RT). At the Iridium Netwerk in Antwerp, one of the 3 Belgian intra-operative radiotherapy (IOeRT) linear accelerators is available for treatment of breast cancer patients both for a boost to the primary tumour bed (for high-risk patients) and for single-dose partial breast irradiation. Combining our existing experience with IOeRT for breast cancer patients with the installation of the ElectronFlash research machine paves the way to compare conventional with FLASH dose rates for radiation therapy using IOeRT irradiators. This set-up will be used to 1- decipher the fundamental biological mechanisms underlying the FLASH effect and 2- prepare a safe and efficacious clinical translation of breast cancer treatment by FLASH IOeRT using preclinical breast cancer and normal tissue models, along with combinatory treatments.
Thereby, our research project aims at investigating both the mechanisms of the FLASH effect and use preclinical models to prepare the translation of FLASH-RT to the clinics:
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