PhD Candidate

     
Employer
Published
WorkplaceFlemish Region, Ghent, Belgium
Category
Position

Description

PhD candidate

Master of pharmaceutical sciences, biomedical sciences, veterinary sciences, bioscience engineering or medicine.

Job description

The neurogenetics team is looking for a highly motivated PhD candidate for a project focusing on TDP-43-mediated neurodegeneration. TDP-43 proteinopathy plays a crucial role in amyotrophic lateral sclerosis and frontotemporal dementia but the pathogenic mechanisms remain poorly understood. Within this project, you will be involved in a detailed characterization of a novel genetic defect in the gene coding for TDP-43 leading to an unusual clinical phenotype. You will use patient samples, CRISPR/Cas9-modified iPSCs and Drosophila models. Techniques will include genetic screening, RNA-seq, proteomics, Western blotting, PCR, immunohostochemistry and single-cell genomics/transcriptomics.

Profile of the candidate

The candidate should have a strong interest in genetics of neurodegenerative disease, good communication and writing skills (English), and should be able to work independently, as well as function as part of a team.

How to apply

We offer a position for 1 year with the possibility of extension for 4 years in case of a positive FWO/BOF application. The candidate will have to apply for an FWO PhD-fellowship in February 2020. Please send your letter of motivation and curriculum vitae to Prof. Dr. Bart Dermaut ( bart.dermaut [at] ugent[.]be ) before June 10, 2019.
Web www.ugent.be/en...
In your application, please refer to myScience.be
and reference  JobID 1857.