Postdoctoral position - Laboratory of Translational Genetics - VIB/KU Leuven

     
Employer
Published
WorkplaceLeuven, Flemish Region, Belgium
Category
Position
Occupation rate10%

Description

Postdoctoral position - Laboratory of Translational Genetics - VIB/KU Leuven

Interested to shape and lead single-cell analysis projects ?

In your role as postdoc,

  • You will have the opportunity to shape and lead single-cell analysis projects to elaborate why immune cells behave differently in the tumor micro-environment in terms of cancer immunotherapy response. 
  • You will be in charge and spearheading this exciting and state-of-the-art research project, but you must also have good communication skills, have a collaborative spirit and be willing to work as part of a research team. 
  • You provide advice and guidance to PhD candidates where applicable. 
  • You need to be able to organize and trouble shoot your work independently, document it thoroughly and communicate results and experience with the team in a transparent and professional manner. 

The Laboratory of Translational Genetics (headed by Diether Lambrechts) at the VIB Center for Cancer Biology (CCB) and Center for Human Genetics at KU Leuven is located in the University Hospital Campus, Leuven, Belgium. The lab has longstanding collaborations with oncologists at the University Hospital Leuven and conducts translational research in numerous clinical trials run by the oncologists. Currently, the lab is capitalizing on these connections with an ambitious new initiative that aims to merge the exciting new field of single-cell analysis with clinical studies collecting tumor biopsies serially sampled from patients treated with immune checkpoint inhibitors and/or angiogenesis inhibitors. Via a single-cell accelerator initiative, the lab has early access to the newest single-cell multi-omics technologies (scRNA-seq, ATAC-seq, DNA-seq, CITE-seq, CROP-seq and spatial profiling). Currently, the major focus of the lab is to characterize how the tumor micro-environment determines tumor behavior and response to cancer therapies. This exciting and actual research line bears a lot of translational potential, as managing the levels of hypoxia in solid tumors by anti-angiogenic strategies represents a major yet incompletely understood challenge, while the field of immunotherapy is rapidly expanding - yet desperately in need of biomarkers predicting clinical response. Selected publications: 1. Thienpont et al. Tumor hypoxia causes DNA hypermethylation by reducing TET activity. Nature 2016;537(7618): p. 63-68. 2. Lambrechts et al. Phenotype molding of stromal cells in the lung tumor microenvironment. Nature Medicine 2018;24(8):1277-128.

The Laboratory of Translational Genetics (headed by Diether Lambrechts) at the VIB Center for Cancer Biology (CCB) and Center for Human Genetics at KU Leuven is located in the University Hospital Campus, Leuven, Belgium. The lab has longstanding collaborations with oncologists at the University Hospital Leuven and conducts translational research in numerous clinical trials run by the oncologists. Currently, the lab is capitalizing on these connections with an ambitious new initiative that aims to merge the exciting new field of single-cell analysis with clinical studies collecting tumor biopsies serially sampled from patients treated with immune checkpoint inhibitors and/or angiogenesis inhibitors. Via a single-cell accelerator initiative, the lab has early access to the newest single-cell multi-omics technologies (scRNA-seq, ATAC-seq, DNA-seq, CITE-seq, CROP-seq and spatial profiling). Currently, the major focus of the lab is to characterize how the tumor micro-environment determines tumor behavior and response to cancer therapies. This exciting and actual research line bears a lot of translational potential, as managing the levels of hypoxia in solid tumors by anti-angiogenic strategies represents a major yet incompletely understood challenge, while the field of immunotherapy is rapidly expanding - yet desperately in need of biomarkers predicting clinical response. Selected publications: 1. Thienpont et al. Tumor hypoxia causes DNA hypermethylation by reducing TET activity. Nature 2016;537(7618): p. 63-68. 2. Lambrechts et al. Phenotype molding of stromal cells in the lung tumor microenvironment. Nature Medicine 2018;24(8):1277-128.

We are looking for a computational immunologist who is highly motivated, well organized and dynamic with a high level of independence and creative thinking,

  • PhD with a topic in one of the following areas: (cancer) immunology, bioinformatics,computational biology, molecular biology or similar
  • Abroad bioinformatics experience with a good working knowledge of genomics /pathway biology / (cancer) immunology and deep scientific expertise in next generation sequencing technologies and (statistical) data analysis. Experience in single-cell sequencing is not required, but considered a plus. Practical skills (wet lab activities) in molecular biology/immunology are also a plus
  • Working proficiency in appropriate programming languages and software (eg. R, Python)
  • A proven and successful publication track record in this field
  • High intrinsic motivation and a strong scientific curiosity
  • Ability to be inventive and to present novel ideas in method development, data analysis and interpretation.
  • Teamplayer that can work independently in a multidisciplinary (international) team. Excellent oral and written English communication skills
  • Proactive,flexible, and problem-solving attitude
  • Experience in working with deadlines and being involved in multiple projects.

KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR [at] kuleuven[.]be.

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In your application, please refer to myScience.be and reference JobID 2771.

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