Katholieke Universiteit te Leuven (KU Leuven)

Two postdoc positions in single-cell multi-omics to study stem cell and developmental biology

 
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WorkplaceLeuven, Flemish Region, Belgium
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Position

Description

Two postdoc positions in single-cell multi-omics to study stem cell and developmental biology

You will be responsible for leading and continuing exciting single-cell analysis research projects ongoing in the lab to characterize iPS cell reprogramming using scNMT-seq (position 1) and to define regulatory programs underlying the first cell fate decisions of human life using single-cell multi-omics, pluripotent stem cells and embryos, gene editing and synthetic biology (position 2).
You will work collaboratively within and beyond the research team.
You assist, supervise and mentor PhD candidates where needed.
You plan, organize and troubleshoot your work independently, document and communicate your results professionally with colleagues within the team and with collaborators.
You are involved in writing manuscripts, progress reports and grants.

The Laboratory of Cellular Reprogramming and Epigenetic Regulation headed by Vincent Pasque is located at the University Hospital Campus, Leuven, Belgium. The lab performs fundamental research in the area of stem cell and developmental biology. The lab is currently leveraging the exciting development of new single-cell omics technologies to increase our understanding of how cell identity is regulated during cellular reprogramming to pluripotency and early mammalian development. Through the new Leuven Single-Cell Omics Institute, the lab has access to the latest single-cell multi-omics technologies (scRNA-seq, scATAC-seq, scG&T-seq, scNMT-seq, CROP-seq, spatial transcriptomics, CYTOF). The current focus of the lab is 1) to define how chromatin silencing is reversed during somatic cell reprogramming to induced pluripotent stem cells (iPS cells) and 2) to characterize how gene regulatory programs and cell fate decisions are regulated during early human development, with a particular interest in pluripotent stem cells. These fundamental questions have important implications for regenerative medicine because therapies based on pluripotent stem cell-derived cell products are moving into clinical trials, yet there is a need to better recapitulate developmental programs in a dish for cell replacement therapy and disease modelling purposes. Selected publications: 1. Janiszewski, Talon et al. Dynamic Erasure of Random X-Chromosome Inactivation during iPSC Reprogramming. Genome Research. 2019, 29 (10), 1659-1672. 2. Pasque, Tchieu et al. X chromosome-reactivation dynamics reveal stages of reprogramming to pluripotency. Cell. 2014. 18;159(7):1681-97.

The Laboratory of Cellular Reprogramming and Epigenetic Regulation headed by Vincent Pasque is located at the University Hospital Campus, Leuven, Belgium. The lab performs fundamental research in the area of stem cell and developmental biology. The lab is currently leveraging the exciting development of new single-cell omics technologies to increase our understanding of how cell identity is regulated during cellular reprogramming to pluripotency and early mammalian development. Through the new Leuven Single-Cell Omics Institute, the lab has access to the latest single-cell multi-omics technologies (scRNA-seq, scATAC-seq, scG&T-seq, scNMT-seq, CROP-seq, spatial transcriptomics, CYTOF). The current focus of the lab is 1) to define how chromatin silencing is reversed during somatic cell reprogramming to induced pluripotent stem cells (iPS cells) and 2) to characterize how gene regulatory programs and cell fate decisions are regulated during early human development, with a particular interest in pluripotent stem cells. These fundamental questions have important implications for regenerative medicine because therapies based on pluripotent stem cell-derived cell products are moving into clinical trials, yet there is a need to better recapitulate developmental programs in a dish for cell replacement therapy and disease modelling purposes. Selected publications: 1. Janiszewski, Talon et al. Dynamic Erasure of Random X-Chromosome Inactivation during iPSC Reprogramming. Genome Research. 2019, 29 (10), 1659-1672. 2. Pasque, Tchieu et al. X chromosome-reactivation dynamics reveal stages of reprogramming to pluripotency. Cell. 2014. 18;159(7):1681-97.

Position 1: Single-cell multi-omics to understand iPS cell reprogramming o Broad experience working with bioinformatics and good knowledge in next generation sequencing technologies and data analysis.
o Experience with single-cell sequencing is not required but an advantage. Wet lab skills in molecular and stem cell biology are a plus.

Position 2: Single-cell omics and pluripotent stem cells to understand the origins of human life o Experience with cell culture and molecular biology.
o Experience with human pluripotent stem cells and genome editing is not required but an advantage.
o Experience with early mammalian development is also an advantage.
o Experience with next generation sequencing technologies is a plus.

For both positions: o You have a PhD degree in cell biology, bioinformatics, molecular biology or related field.
o Knowledge of and competent working in programming languages and software (R, Python).
o You have at least 1 good first author publication or preprint.
o You have a good command of spoken and written English.
o Collegial/team player mentality, independence and problem-solving skills are expected.

KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR [at] kuleuven[.]be.

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In your application, please refer to myScience.be and reference JobID 3008.

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