Katholieke Universiteit te Leuven (KU Leuven)

Post-Doctoral Position in Endothelial Cell Heterogeneity

 
Published
WorkplaceLeuven, Flemish Region, Belgium
Category
Position

Description

POST-DOCTORAL POSITION IN ENDOTHELIAL CELL HETEROGENEITY

  • you will have a dedicated project related to the aims described above and be responsible for its administration and execution
  • you will be collaborating with other team members working on endothelial heterogeneity in the liver as well as in other organs
  • your project will involve working with transgenic animal models, cell isolation and culture and collection of human samples for further expression profiling
  • you will be expected to present your work at internal and external (inter)national meetings


Context: A post-doctoral position in the context of a recently granted 4-year KU Leuven competitive funding C1 project is available in the Endothelial Cell Biology Research Unit, headed by Prof. Dr. Aernout Luttun, at the Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Belgium. Background and aims of the project: All organs, with a few exceptions, contain a blood vessel network that is adapted to fulfill the needs of the host tissue. The endothelial cells lining the inside of these vessels have therefore acquired specific molecular, morphologic and functional characteristics that become compromised when exposed to disease conditions. Unraveling the mechanisms that determine these organ-specific endothelial characteristics and understanding the changes induced by disease offers the possibility to develop novel strategies to diagnose and treat organ-specific diseases. The current project focusses on endothelial cells in the liver as well as lymphatic endothelial cells which have several characteristics in common. The host lab identified a transcription factor highly expressed in liver endothelial cells that plays a role in maintenance of liver blood vessels and during liver fibrosis. The aims of this project are to better understand the differential mode of action of this transcription factor in liver endothelial cells and related lymphatic endothelial cells and to use mouse and human samples to explore the role of liver endothelial cells during development of non-alcoholic fatty liver disease, currently becoming the most common chronic liver disease.

Context: A post-doctoral position in the context of a recently granted 4-year KU Leuven competitive funding C1 project is available in the Endothelial Cell Biology Research Unit, headed by Prof. Dr. Aernout Luttun, at the Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Belgium. Background and aims of the project: All organs, with a few exceptions, contain a blood vessel network that is adapted to fulfill the needs of the host tissue. The endothelial cells lining the inside of these vessels have therefore acquired specific molecular, morphologic and functional characteristics that become compromised when exposed to disease conditions. Unraveling the mechanisms that determine these organ-specific endothelial characteristics and understanding the changes induced by disease offers the possibility to develop novel strategies to diagnose and treat organ-specific diseases. The current project focusses on endothelial cells in the liver as well as lymphatic endothelial cells which have several characteristics in common. The host lab identified a transcription factor highly expressed in liver endothelial cells that plays a role in maintenance of liver blood vessels and during liver fibrosis. The aims of this project are to better understand the differential mode of action of this transcription factor in liver endothelial cells and related lymphatic endothelial cells and to use mouse and human samples to explore the role of liver endothelial cells during development of non-alcoholic fatty liver disease, currently becoming the most common chronic liver disease.

Candidates need to have a PhD degree in a relevant discipline (e.g.Biological Sciences) and have a background and experience in preferably multiple aspects mentioned in the project description. We seek a highly motivated and enthusiastic individual with good communication and writing skills in English and the ability to guide and supervise (a) PhD candidate(s). A general good proficiency in molecular and cellular biology techniques (including qRT-PCR, RNAseq (including analysis), Western blot, ChIP, lentivirus production and cell transduction, FACS, cell culture), histology and (transgenic) animal models is an important asset. A good publication record with a least one publication in a higher-impact journal will be valued.

KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR [at] kuleuven[.]be.

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In your application, please refer to myScience.be and reference JobID 3026.

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