Junior/senior postdoc neurobiology

 
Published
WorkplaceLeuven, Flemish Region, Belgium
Category
Position

Description

Within the ASAP program we recruit a highly skilled and motivated junior/senior postdoc to strengthen the multidisciplinary team of academic partners. In particular, we look for an experienced Neurobiologist to characterize the phenotype and pathways of neurodegeneration in ATP13A2 and ATP10B KO mice, while performing omics analyses on tissue and biofluids.

The laboratory of Cellular Transport Systems, headed by Prof. Peter Vangheluwe, recently published ground-breaking insights in the underlying molecular and cellular defects in Parkinson’s disease (Van Veen and Martin et al, Nature, 2020; Martin and Smolders et al, Acta Neuropathologica, 2020). Research of his team focuses on the P-type ATPases ATP13A2 (PARK9) and ATP10B, two transporters that are genetically implicated in Parkinson’s disease. They’ve established that ATP13A2 removes polyamines out of the lysosome, whereas ATP10B is a lysosomal exporter of the sphingolipid glucosylceramide; both lysosomal functions exert potent neuroprotective effects. Based on these novel molecular insights we will study the phenotype of ATP13A2 and ATP10B KO mouse models, and investigate cross-talk with other established pathways of neurodegeneration. This study is part of the research project IMPACT-PD, a highly prestigious and international collaborative research initiative funded by the Aligning Science Across Parkinson’s (ASAP) program.

The laboratory of Cellular Transport Systems, headed by Prof. Peter Vangheluwe, recently published ground-breaking insights in the underlying molecular and cellular defects in Parkinson’s disease (Van Veen and Martin et al, Nature, 2020; Martin and Smolders et al, Acta Neuropathologica, 2020). Research of his team focuses on the P-type ATPases ATP13A2 (PARK9) and ATP10B, two transporters that are genetically implicated in Parkinson’s disease. They’ve established that ATP13A2 removes polyamines out of the lysosome, whereas ATP10B is a lysosomal exporter of the sphingolipid glucosylceramide; both lysosomal functions exert potent neuroprotective effects. Based on these novel molecular insights we will study the phenotype of ATP13A2 and ATP10B KO mouse models, and investigate cross-talk with other established pathways of neurodegeneration. This study is part of the research project IMPACT-PD, a highly prestigious and international collaborative research initiative funded by the Aligning Science Across Parkinson’s (ASAP) program.

Experience with mouse models of neurodegeneration (Immunohistochemistry, behavioral phenotyping, mice breeding), a background in Parkinson’s disease mechanisms, and lysosomal/mitochondrial biology are strong assets

PhD degree (max 5 years) in Medical or Biomedical Sciences, Bioengineering, (Neuro)biology, or equivalent.

Good time and project management skills to adhere to strict project deadlines and milestones.

Effective communicator, reporting results in the team and in consortium meetings

Excellent team player, working in an international and multidisciplinary team to reach common goals

KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR kuleuven.be.

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In your application, please refer to myScience.be and reference JobID 3971.


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