Postdoctoral fellow

WorkplaceFlemish Region, Ghent, Belgium


PhD in the field of immunology, developmental biology, bioinformatics or related

Job description

The research group of Tom Taghon ( ?" target="_blank" rel="nofollow"> ), located in Ghent, Belgium, is looking for a talented and highly motivated postdoctoral fellow to join our team. Research in our lab is focused on the functional characterization of the molecular mechanisms that control major developmental stages of T cell development in human. We aim to better understand how functional T cells are generated so that this can be exploited to understand mechanisms of disease (such as immune deficiencies and T-ALL) and to improve current strategies for designing cell therapy approaches (such as CAR T-cells).

Using human primary hematopoietic stem cells and thymocytes, successful candidates will apply state-of-the-art molecular and cell culture approaches to improve our understanding on how human ?? and ?? T cells are generated. The work builds further on recent papers from the lab (Park et al., Science 2020; Lavaert et al., Immunity 2020; Roels et al., Nature Immunology 2020) and incorporates techniques such as single cell RNAseq, CITEseq and ATACseq; ChIPseq and CUT&TAG, in vitro cell cultures and organoids for hematopoietic stem cell differentiation (Dolens and Taghon, Nature Methods 2017) and retro- and lentiviral perturbation experiments for gain- and loss-of-function studies (including CRISPR/Cas9). You will work together with an international group of postdocs, PhD candidates and technicians in a new research building on the Ghent University Hospital campus that houses leading research groups in the field of Immunology and Genetics, thereby providing a state-of-the-art and stimulating research environment.

Profile of the candidate

Candidates should have a relevant PhD in the field of immunology, developmental biology, bioinformatics or related. You have excellent knowledge and skills in molecular biology and/or tissue culture and preferentially also in bioinformatics and RNAseq/ChIPseq data analysis. You are creative, highly motivated and a team player with good reporting and writing skills in English. Applicants should have a competitive publication record in peer-reviewed international journals with at least one paper as a first author.

How to apply

For further information or to apply (include motivation letter, contact details of 2-3 referees and curriculum vitae with publication list and research experience), please contact : Prof. Dr. Tom Taghon (E-mail: Tom.Taghon )


In your application, please refer to and reference JobID 4004.

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