PhD Candidate Pharmacological induction of autophagy

WorkplaceAntwerpen, Flemish Region, Belgium


If you want to learn more about career opportunities within YUFE (Young Universities for the Future of Europe) , check out the YUFE vacancy page and YUFE website .

Department: Department of Pharmaceutical Sciences
Regime Full-time

The Faculty of Pharmaceutical, Biomedical and Veterinary Sciences and the faculty of Medicine and Health Sciences are looking for a full-time PhD candidate in the field of Pharmacological induction of autophagy.

This PhD project is embedded in a larger Concerted Research Action project (GOA) to validate autophagy induction as a therapeutic strategy. In total, three PhD candidates will work in a complementary way to create new knowledge and tools to obtain readily translatable preclinical results in this exciting research field of autophagy induction.

This PhD project will be executed in two research groups:

The Toxicological Center (TC) : The research group focuses on the development and validation of bioanalytical platforms based on chromatography and mass spectrometry to be used in metabolomics and environmental and forensic toxicology. The laboratory has state-of-the-art instrumentation such as 2-dimensional liquid chromatography-ion mobility-high resolution mass spectrometry. Within this PhD project, the student will use metabolomics approaches based on liquid chromatography and high resolution mass spectrometry to investigate metabolic fingerprints of autophagy induction to elucidate its mode-of-action and to identify possible (sets of) biomarkers of autophagy induction.

Molecular Imaging and Radiology Group (MIRA): The research group focuses on the development and validation of nuclear imaging probes for improved diagnosis, stratification and treatment response evaluation in cancer and neurodegenerative diseases. It has access to a fully equipped preclinical nuclear imaging lab (MICA) at UA and the cyclotron/GMP radiopharmacy at UZA. Within this PhD project the student will evaluate the oncogenic potential of newly developed autophagy inducers in a variety of cancer models using different imaging modalities (bioluminescence, PET and CT) to monitor tumor growth. Results in vivo will be correlated with ex vivo markers of autophagy induction using immunohistochemical stainings, transmission electron microscopy and metabolomics.

Job description:

A challenging PhD project in which we apply imaging, biochemical and bioanalytical experiments in two different research groups.

The research will be performed at the molecular, cellular and organismal level.

The project will make use of several state-of-the-art and rapidly advancing technologies in imaging biochemistry, analytical chemistry, metabolomics, molecular biology, cell biology and pharmacology

The project will offer training, participation to congresses and international collaboration.

Profile and requirements:

You must hold an Academic Master recognized by the EU in one of the following disciplines: biochemistry, biology, bioengineering, biomedical or pharmaceutical sciences.

Outstanding academic study performances; according to ECST grading scale and recognized by the EU.

FELASA C degree (or EU equivalent) for handling small model organisms is obligatory. Candidates who do not have a FELASA C degree are willing to follow courses to obtain this degree at the start of the PhD project.

Expertise or knowledge in analytical chemistry, molecular and cellular biology, statistics and bioinformatics.

Strong interest in basic research, metabolomics, pharmacology and the molecular mechanisms of neuroscience and vascular disease.

Your research qualities are in line with the faculty and university research policies .

What we offer

We offer a doctoral scholarship for the first year. The applicant is expected to defend an innovative PhD project at the FWO-Flanders (see guidelines: ?" target="_blank" rel="nofollow"> ). If not granted, obtaining adequate ranking for this competitive doctoral scholarship will result in a contract for a period of at least one additional year with possibility for re-application the next year.

The planned start date is 1 March 2021 or as soon as possible after that date.

Your monthly scholarship amount is calculated according to the scholarship amounts for doctoral scholarship holders on the pay scales for contract research staff (Dutch: Bijzonder Academisch Personeel, BAP).

You will do most of your work at Campus Drie Eiken in a dynamic and stimulating working environment.

How to apply:

You can apply for this vacancy through the University of Antwerp’s online job application platform up to and including 1 February 2021 (by midnight Brussels time). Click on the 'Apply' button, complete the online application form and be sure to include the following attachments: a motivation letter and your CV.

The selection committee will review all of the applications as soon as possible after the application deadline. Selected candidates will be invited for an interview in February and will be informed about the remainder of the selection procedure.

If you have any questions about the online application form, please check the frequently asked questions or send an email to jobs . If you have any questions about the specific PhD project please contact: Prof. Dr. Alexander van Nuijs (Toxicological Center; alexander.vannuijs ) / Prof. Dr. Sigrid Stroobants (Molecular Imaging and Radiology; sigrid.stroobants )

The University of Antwerp received the European Commission’s HR Excellence in Research Award for its HR policy. We are a sustainable, family-friendly organisation which invests in its employees’ growth. We encourage diversity and attach great importance to an inclusive working environment and equal opportunities, regardless of gender identity, disability, race, ethnicity, religion or belief, sexual orientation or age. We encourage people from diverse backgrounds and with diverse characteristics to apply.

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In your application, please refer to and reference JobID 4263.

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