PhD Candidate Medicinal Chemistry

WorkplaceAntwerpen, Flemish Region, Belgium


Department: Department of Pharmaceutical Sciences
Regime Full-time

The Faculty of Pharmaceutical, Biomedical and Veterinary Sciences at the University of Antwerp is seeking to fill a full-time (100%) vacancy in the Department of Pharmaceutical Sciences for a

PhD candidate in the area of Medicinal Chemistry.

Job description

You will be working in the research group Medicinal Chemistry (UAMC) on one of the following research topics:

Research topic 1: Discovery of novel small molecule autophagy inducers. You will be working on optimization, synthesis and primary biological evaluation of autophagy-inducing compounds that have been discovered via High Throughput Screening. Optimal molecules will be investigated in preclinical animal models of peripheral neuropathies and cardiovascular disease through on-campus collaborations. This project is supported by FWO and BOF funding.

Research topic 2: Discovery of selective inhibitors and activity-based probes for Family S9b proteases. The S9b family contains proline-selective serine proteases, several of which are drug targets, e.g. for type II diabetes (DPP4) or oncology (FAP). You will work on the design and synthesis of new molecules that can specifically target individual representatives of the S9b family. Your compounds will be validated in enzymatic, cellular assays and -if successful- in in vivo animal models. This project is supported by FWO funding.

Next to experimental research, you will write project reports for your supervisor on a regular basis, write scientific papers and support grant writing.

Profile and requirements

You hold a Master’s degree in Chemistry, Pharmaceutical Sciences, Biochemistry or Chemical Engineering, and you preferably have some experience with synthetic organic chemistry and/or medicinal chemistry

You are expected to apply for a doctoral grant with the Flemish Science Foundation (FWO) in the 2021 and/or 2022 call.

You will be required to enroll in the Antwerp Doctoral School.

Your academic qualities comply with the requirements stipulated in the university’s policy .

We offer

An appointment as a PhD candidate for a period of one year, with a possibility of renewal for 3 additional years.

Your monthly salary is calculated according to the pay scale for PhD candidates.

Click here to find out more about working at the University of Antwerp and the related benefits.

How to apply?

You can apply for this vacancy through the University of Antwerp’s online job application platform up to and including 8 February 2021 (by midnight Brussels time). Click on the 'Apply' button, complete the online application form and be sure to include the following attachments: a motivation letter and your CV.

The remainder of the selection procedure is specific to the position and will be determined by the selection panel. Interviews will take place in February (exact date will be communicated).

If you have any questions about the online application form, please check the frequently asked questions or send an email to jobs . For questions about the profile and the description of duties, please contact Prof. Pieter Van der Veken ( pieter.vanderveken )

The University of Antwerp is a family friendly organization, with a focus on equal opportunities and diversity. Our HR-policy for researchers was awarded by the European Commission with the quality label HR Excellence in research . We support the Science4Refugees initiative and encourage asylum-seeking, refugee scientists and researchers to apply for a job at the University of Antwerp.

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In your application, please refer to and reference JobID 4271.

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