Crack in the wall of WHO’s top priority pathogens

Schematic representation of the formation of the SlyB nanodisc within phospholip
Schematic representation of the formation of the SlyB nanodisc within phospholipid ’spills’ (pink) in the outer membrane. SlyB forms a ’lifebuoy’ around the spills and embedded proteins (green), thus protecting the outer membrane of the bacteria from rupturing.
In a breakthrough discovery, scientists from VIB-VUB Center for Structural Biology unraveled the mysteries of SlyB, a tiny but mighty protein found in the outer membrane of certain bacteria. When bacteria face stress, SlyB acts as a crucial guardian to protect the bacterial cell from dying. This discovery not only deepens our understanding of bacterial survival mechanisms but also paves the way for potential applications in antimicrobial research. The findings are published in Nature.

Bacteria on the WHO blacklist

Biologists categorize bacteria into two major groups: Gram-positive bacteria, characterized by a single membrane, and Gram-negative bacteria, distinguished by an inner and outer membrane. ...
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