An interdisciplinary team from the Luxembourg Centre for Systems Biomedicine (LCSB) at the University of Luxembourg, together with international collaborators, established that a combination of small variations in genes regulating mitochondria, an important component of human cells, is associated with a higher risk for Parkinson’s disease. For the first time in the field, the researchers demonstrated that these genetic predictions translate into mitochondrial dysfunction in cellular models derived from Parkinson’s patients with a high polygenic risk score. Importantly, using data from a recent clinical trial for a drug targeting mitochondria, they also showed that Parkinson’s patients with high risk scores responded better to the treatment. ...
Genetic risk scores for Parkinson’s for precision medicine approach
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