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On average, we're living longer, but we're not necessarily remaining healthy for longer. Prof Ivan Bautmans, head of the Frailty in Ageing research group at the Vrije Universiteit Brussel, wants to change this. Based on his expertise in gerontology, the study of ageing, he is coordinating an advisory group of the World Health Organization (WHO) with a focus on healthy ageing.

In Belgium, 40% of people waiting for a transplant are unable to find an organ and therefore have to wait, which is why it is so important to guarantee the success of transplants. One of the major factors in failure is inappropriate dosages of the anti-rejection drug tacrolimus . University of Louvain (UCLouvain)-s Laure Elens and Laure Bindels have uncovered the influence of intestinal microbiota in the variability of the drug's dosages.

According to a series of reports published by WHO and the partner study Health Behaviour in School-aged Children (HBSC), adolescents who are most likely to have suffered from negative impacts of the COVID-19 pandemic are female, older, from less affluent families, faced prolonged school closures or lacked social support.

Loss of nerve cells is a process that can take place not only in the brain, but also in the (less well-known) nervous system in the gut. A new study, carried out at KU Leuven and published in Nature , shows that specialised immune cells shape this nervous system, enabling the gut to make the transition to solid food early in life.

Currently, only a meagre 1% of the vaccines needed for Africa are produced locally. The ambition is to raise this number to 60% by 2040. Together, KU Leuven and the Institut Pasteur of Dakar are working to overcome several significant challenges, including the need for continuous cooling, time-consuming methods for certain blood analyses in clinical studies, and the lack of vaccines against several deadly tropical diseases.

Because of the large number of different cell types in brain tumors, all of which respond differently to treatment, many patients relapse, and the chances of full recovery are very slim. A new diagnostic test, developed by KU Leuven, indicates from a biopsy whether a treatment can attack all the tumor cells present.

Researchers from the Vrije Universiteit Brussel and the EPFL in Lausanne, Switzerland, have developed a highly efficient method for rapid testing the sensitivity of bacteria to antibiotics. The technique, optical nanomotion detection (ONMD), is extremely fast, precise to a single cell and requires only a traditional microscope equipped with a camera or a mobile phone.

Immunotherapy is a powerful way to treat cancer patients but up till now, it was hard to predict why some patients or cancer types do not benefit from this treatment. Researchers could identify markers which predict a patient's or cancer type's response to immunotherapy. For some cancers, immunotherapy can be integrated into the standard treatment but for others, further research is needed to either alter the immunological environment with cancer vaccines or to develop a new type of immunotherapies that target the tumour in another manner.

David Tewodrose and Harry Zekollari are two of 13 researchers to receive a prestigious Odysseus grant, a start-up fund from the Research Foundation - Flanders (FWO). They will be based at the Vrije Universiteit Brussel for the next five years to develop their research practice. Tewodrose focuses on geometric analysis that is used in medical applications, among other uses.

COVID-19, caused by an infection with the SARS-CoV-2 virus, was declared a global pandemic by the World Health Organisation (WHO) in March 2020. While some people developed severe illness and required medical care, many people reported only mild-to-moderate symptoms, if any at all. However, many of the infected individuals have experienced persisting symptoms or frequent other infections months after the initial infection even if they weren-t much impacted by the disease to begin with.

Regular exercise may protect pancreatic beta cells from stresses that contribute to diabetes. Researchers from the ULB Center for Diabete Research observed this in a study published in Diabetologia . Diabetes is characterized by a progressive loss of pancreatic beta cells, the same cells that produce insulin and thus maintain the right level of sugar in the blood.

A team led by Prof Kiavash Movahedi (VUB, VIB) has mapped in detail how the immune system acts against pathogens invading the brain. The findings shed new light on host-pathogen interactions and the long-term consequences of brain infections. The results, published in the renowned journal Immunity, show how different types of immune cells are involved in the defence against brain infections.

Researchers at KU Leuven have discovered a promising new method for the treatment of metastatic prostate cancer. In such cases, conventional treatments involve the use of medication to suppress or inhibit the patient's male hormones in order to slow down the disease. After some time, however, the cancer cells become resistant to that medication.

Gamma delta (γδ) T cells are immune system cells that possess several characteristics that make them attractive cellular targets for cancer immunotherapy. A team of researchers sought to better understand the development of these T cells in humans. Gamma delta (γδ) T cells are of increasing interest as target cells for cancer immunotherapy.

When a tumor develops in an organism, it is very common for the cancer cells to leave the tumor and settle in another organ where they proliferate, creating what is called metastasis. This process is an important factor in mortality since it means the worsening of the disease. Hence the interest in better understanding what happens during this phenomenon.

In a large epidemiological study researchers from KU Leuven show that patients with an autoimmune disorder have a substantially higher risk of developing cardiovascular disease than individuals without autoimmune disease. The research shows for the first time that cardiovascular risks affect autoimmune disorders as a group of diseases with implications across a broad range of cardiovascular outcomes.

In brief: Chronic kidney disease (CKD) affects over 10% of the world's population, including over one million people in Belgium. Genetic mutations are a major cause of CKD. Some mutations are very rare and have very severe effects on the kidney. Others are much and have barely detectable effects. For the first time, a UCLouvain team has discovered an intermediate-effect genetic mutation, present in about one in 1,000 people, that strongly increases the risk of CKD.

Ghent University research in Burkina Faso: fortified food supplements increase the chance of a healthier baby Every parent around the globe wishes for a healthy baby.

Successful and unsuccessful approaches to the pandemic by Western governments Tuesday, May 17, 2022 — Since 2020, the world has been experiencing the consequences of the Covid-19 pandemic. The cause is obviously a virus, but the degree of its spread, and the associated number of infections and deaths, is largely dependent on socio-economic factors.

Not every type of greenery in an urban environment has the same positive effect on people. One large tree with a robust crown has more impact than ten young trees. That is the conclusion of a large-scale study by KU Leuven that was published today in the influential journal Environmental Health Perspectives.