Ghent University researcher Mo Lamkanfi wins an ERC Proof of Concept Grant. With this grant, he aims to identify new anti-inflammatories that could be used in gout, atherosclerosis, Alzheimer’s disease, Parkinson’s disease and multiple sclerosis.
Proof of Concept Grants funded by the European Research Council (ERC) have just been offered to fifty-five successful frontier researchers (out of 120 evaluated proposals). Worth ¤150 000 each, the grants will be used to explore the commercial or societal potential of the results of their research projects. Mo Lamkanfi is the only Belgian researcher in this round.
Discover the project of Mo LamkanfiIn the PyroScreen project, Mo Lamkanfi aims to identify new prototype anti-inflammatories that potently and selectively block the activity of the NLRP3 inflammasome.
Inflammatory mechanisms are inadvertently activated in many chronic diseases, thus contributing to the disease process. For example, the NLRP3 inflammasome plays a crucial role in chronic inflammatory diseases such as gout and pseudogout, in metabolic diseases such as atherosclerosis and fatty liver, and in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and multiple sclerosis. Furthermore, congenital mutations in the NLRP3 gene cause three hereditary diseases collectively known as cryopyrin-associated periodic syndrome (CAPS).
Due to the broad involvement of NLRP3 in various disease indications, selective and potent inhibitors of the NLRP3 inflammasome may have broad therapeutic potential. Early clinical studies with first-generation NLRP3 inflammasome inhibitors are currently underway. A major concern here is that these drug candidates all belong to the same prototype, which significantly increases development risks. To increase the chance of success, there is therefore an urgent need for new prototype molecules that can block the NLRP3 inflammasome.
PyroScreen builds on the research in the ERC Consolidator Grant PyroPOP in which the research group has gained important insights into the mechanism of action of the NLRP3 inflammasome and how inhibitors of the first-generation act on it. In PyroScreen, the researchers now want to use this knowledge and know-how to lay the foundation for the development of second-generation NLRP3 anti-inflammatories that act potently and selectively on this crucial inflammation mechanism.